Oxides and ultramarines are commonly used as a colorant in many skin care products such as soaps, lotions, shampoos, make-up etc. They were originally natural minerals and clays mined from the earth, but there was one big problem- in the same earth came arsenic, lead, and mercury, just to name a few. These toxic metals were obviously a great risk to the public until the FDA created regulations that had these minerals manufactured in a lab. On a molecular basis they are the very same thing, only synthetically produced so now you can have the assurance that they're non-toxic. Today, in the United States, only the "cosmetic grade" synthetic versions of these minerals are legal to be used in cosmetic and personal care products.
This is one of those rare instances that goes to show that natural is not always safer. Nowadays it seems like almost everything can be a potential danger in one form o
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